# MOTS-C - A mitochondrial-derived peptide, supplied freeze-dried for laboratory research. MOTS-C mitochondrial peptide research-use-only material - freeze-dried, current certification unverified, dispatched from Perth. ## At a glance | | | | --- | --- | | Compound | MOTS-C | | Descriptor | Mitochondrial-derived peptide | | Current certificate | Not verified for listed lot | | Storage | 2-8 C | | Format | Freeze-dried powder | | Availability | In stock | | Lot | MOT-2506 | ## Sizes and pricing (AUD) | | | | --- | --- | | 10 mg | $99 AUD | ## Certificate status Matching current certificate unavailable. No verified report matches the listed compound, lot and amount. Historical sample report: MOTS-C, 10 mg, lot FL20260410-MOTS-10. Test: Peptide vial assessment. This report does not verify the listed item or lot; a document mismatch does not establish the physical product's contents. ## What MOTS-C is MOTS-C is a 16-amino-acid mitochondrial-derived peptide (MDP), encoded by a short open reading frame inside the mitochondrial 12S rRNA / MT-RNR1 region. MDPs are a small, relatively recent research field; humanin is another commonly discussed example. MOTS-C was first described in 2015, and the commonly cited sequence is MRWQEMGYIFYPRKLR. The cited evidence on this page is mainly cell-culture and mouse work, with human-linked mentions limited to observational or genetic association context. Form Labs supplies the current 10 mg vial as freeze-dried research reference material with a catalog lot record. Matching current certification is unverified. ## Specifications This spec sheet is for identity and paperwork only. It keeps the MT-RNR1 context, sequence, public database identifiers, lot and storage details together for the 10 mg vial. Matching current certification is unverified. | | | | --- | --- | | Compound | MOTS-C | | Full name | Mitochondrial ORF of the 12S rRNA type-c | | Gene context | MT-RNR1 short open reading frame | | Sequence | MRWQEMGYIFYPRKLR | | Length | 16 amino acids | | CAS | 1627580-64-6 (database/catalog identifier) | | Molecular formula | C101H152N28O22S2 | | Molecular weight | 2174.6 g/mol | | Appearance | Freeze-dried | | Lot | MOT-2506 | ## What MOTS-C studies look at Lee and colleagues (2015) described MOTS-C in cell systems and mice, linking the peptide to AMPK through the folate / one-carbon pathway and keeping the finding in model context. Kim and colleagues (2018) reported, in human cell lines under glucose restriction, that MOTS-C moved into the nucleus and was associated with stress-response gene regulation through NRF2 / AMPK. Kumagai and colleagues (2024) reported CK2 binding and activation in mice and cells. The human-linked part of that paper was genetic association work around a natural K14Q variant, not administration research. ## Frequently asked questions ### What is MOTS-C supplied for? MOTS-C is supplied as laboratory research material only. It is 21+ only, not for human consumption, and not for veterinary use. ### Does this page include matching COA information? The product page lists catalog lot, appearance and storage notes for MOTS-C. Available original reports are labelled by sample; matching current certification is unavailable where the compound, lot or amount differs. A heavy-metals screen does not measure purity or confirm identity. ### How should the vial be handled after delivery? Follow the label and your laboratory's written procedures. Do not treat a historical sample report as current lot documentation. This page repeats 2-8 C storage guidance and light-protection notes before checkout. ### What is MOTS-C? MOTS-C is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame inside the mitochondrial 12S rRNA / MT-RNR1 region. First described in 2015, it is studied in cell and animal research for mitochondrial biology and the AMPK energy-sensing pathway. The spec sheet lists the sequence MRWQEMGYIFYPRKLR with formula C101H152N28O22S2 and a molecular weight of 2174.6 g/mol. Form Labs supplies it freeze-dried as reference material for laboratory research only. ### What does MOTS-C stand for? MOTS-C stands for Mitochondrial ORF of the 12S rRNA type-c, where ORF means open reading frame. The name reflects that its gene sits inside the mitochondrial 12S rRNA region rather than in the cell nucleus, which is what makes it a mitochondrial-derived peptide. That gene context appears on the spec sheet alongside the sequence and molecular weight. It is identity information, not a use direction. ### Which batch and storage apply to MOTS-C? The current batch is lot MOT-2506, supplied as a 10 mg freeze-dried vial. The spec sheet describes a freeze-dried appearance, and storage follows the label. The lab report on file for MOTS-C is a Janoshik peptide vial assessment, which measures the peptide content of the vial at 11.15 mg. It covers historical sample lot FL20260410-MOTS-10, not the listed MOT-2506 lot. Matching current certification is unavailable; these are catalog and historical sample details, not current test findings or use instructions. ## References - Lee 2015: Lee C, Zeng J, Drew BG, et al. Cell Metab. 2015;21(3):443-454. DOI: 10.1016/j.cmet.2015.02.009 - Kim 2018: Kim KH, Son JM, Benayoun BA, Lee C. Cell Metab. 2018;28(3):516-524.e7. DOI: 10.1016/j.cmet.2018.06.008 - Kumagai 2024: Kumagai H, Kim SJ, Miller B, et al. iScience. 2024;27(11):111212. DOI: 10.1016/j.isci.2024.111212 This summary is for scientific and educational context only. It is not preparation guidance, administration guidance, or a statement about use in people or animals. --- Canonical page: https://www.formlaboratories.com/shop/mots-c Form Laboratories - Perth-based research-use-only peptide supplier, shipping Australia-wide. - Site guide for agents: https://www.formlaboratories.com/llms.txt - Sitemap: https://www.formlaboratories.com/sitemap.xml - Full catalogue: https://www.formlaboratories.com/shop - Contact: hello@formlaboratories.com All materials are supplied for laboratory research use only - not for human or veterinary use, and nothing on this site is medical advice.