MOTS-C research guide

01 - Short version

The quick read.

Plain-language context only. No preparation steps, no use instructions, and no product-effect claims.

New to MOTS-C? Here's the short version. MOTS-C is a 16-amino-acid mitochondrial peptide encoded within the MT-RNR1 region of mitochondrial 12S rRNA.

MOTS-C is commonly cited with the sequence MRWQEMGYIFYPRKLR.

The existing references look at MOTS-C in cell and mouse systems, AMPK-linked signalling, stress-responsive movement into the nucleus, gene-expression response, GLUT4 and mitofusion context, bone-model systems, and CK2 binding.

02 - What it is

The plain identity details.

Compound: MOTS-C
Full name: Mitochondrial ORF of the 12S rRNA type-c
Gene context: MT-RNR1 short open reading frame
Sequence: MRWQEMGYIFYPRKLR
Length: 16 amino acids
CAS: 1627580-64-6 (database/catalog identifier)
Molecular formula: C101H152N28O22S2
Molecular weight: 2174.6 g/mol
Lot: MOT-2506

Identity information lets you compare the guide with the product label. It is not a certificate, mixing method, or instruction for use.

03 - What studies look at

The main research themes.

Each note stays at study-context level and avoids use instructions.

012015 discovery paperLee et al., Cell Metabolism, 2015.

The paper defines MOTS-C and its mitochondrial coding context.

022018 nuclear-response paperKim et al., Cell Metabolism, 2018.

This is the core stress-responsive mitonuclear signalling paper.

032024 CK2 paperKumagai et al., iScience, 2024.

The paper adds a direct binding target in model systems.

Handling and storage

Storage, appearance, purity, and release state come from the matching lot record.

Use the product label and matching COA as the authority for storage, appearance, purity, and release state.

This guide is educational context only. It does not include preparation, administration, human-use, or veterinary-use directions.

For laboratory research use only. 18+ only. Not for human consumption or veterinary use.

05 - FAQ

Common questions.

What is MOTS-C supplied for?

MOTS-C is supplied as laboratory research material only. It is 18+ only, not for human consumption, and not for veterinary use.

Does this page include matching COA information?

Yes. The product page lists lot, identity, purity, appearance, release status, and storage notes for MOTS-C.

How should the vial be handled after delivery?

Follow the label and matching COA paperwork. This page repeats 2-8 C storage guidance and light-protection notes before checkout.

What is MOTS-C?

MOTS-C is a 16-amino-acid mitochondrial-derived peptide encoded by a short open reading frame within mitochondrial 12S rRNA.

What do MOTS-C papers look at?

The cited papers look at cellular stress signalling, mitonuclear communication, gene-expression response, AMPK-linked pathways, and CK2 binding in model systems.

Why does MOTS-C use generic product imagery?

A dedicated vial image can be added later. Until then, the page uses Form Laboratories product-system imagery while keeping the MOTS-C data specific to this product.

06 - References