What is the molecular formula of retatrutide?

What is the molecular formula of retatrutide?

The molecular formula of retatrutide is C221H342N46O68, published by PubChem CID 171390338 under CAS Registry Number 2381089-83-2. That same record lists a molecular weight of 4731 and an exact mass of 4730.4784689. NCATS Inxight Drugs carries the same CAS number for retatrutide under UNII NOP2Y096GV. A molecular formula is a count of how many atoms of each element sit in one molecule: 221 carbons, 342 hydrogens, 46 nitrogens, and 68 oxygens here. Exact mass means the mass calculated from the specific isotopes in the formula, rather than the averaged weight.

Retatrutide's formula becomes useful only when the record stays attached. PubChem CID 171390338 supplies the formula, molecular weight, exact mass, and CAS Registry Number 2381089-83-2; NCATS Inxight Drugs supplies the matching identifier trail under UNII NOP2Y096GV. Together, those records connect the atom count to the named compound without asking one database to prove what the other does not contain.

The letters name four elements, but they do not draw the molecule. Carbon, hydrogen, nitrogen, and oxygen are the same four elements your own body is mostly built from, and they can be joined in a staggering number of ways. A formula says how many of each. It never says how they are arranged. The peptide structure is therefore a separate layer of evidence from the formula string.

Evidence limits

What does retatrutide's molecular formula not tell you?

Vendor and wiki pages, including Peptide Protocol Wiki, print C228H350N48O66 / 4894.58 Da without a source. That figure conflicts with PubChem CID 171390338, so this page rejects it and follows the registry record. A repeated web listing is not a second chemical measurement.

The PubChem records do not resolve free base against salt, trifluoroacetate, or hydrate forms, and the sodium-salt entry is a registry echo rather than an independent measurement. NCATS Inxight Drugs supplies INN number 12350, but no WHO INN recommended-list document was opened for this review. CAS Common Chemistry returned no formula in this review, so it is not treated as a formula source.

What is retatrutide made of?

Retatrutide is a single peptide — a short chain of amino acids joined end to end — made of 39 amino acids on a GIP peptide backbone (Coskun et al., Cell Metabolism, 2022). The same paper places three non-coded residues, building blocks the body's own protein machinery does not use, at Aib2, αMeL13, and Aib20 (Coskun et al., Cell Metabolism, 2022). Aib means α-amino isobutyric acid, while αMeL means α-methyl-L-leucine. Coskun and colleagues also report a C20 fatty diacid, a long fat-like chain with an acid group at each end, linked at the position 17 lysine, Lys17 (Coskun et al., Cell Metabolism, 2022).

Coskun and colleagues give each engineered residue a job (Coskun et al., Cell Metabolism, 2022). Aib2 supports stability against DPP4, an enzyme that trims peptides of this family. αMeL13 supports glucagon and GIP activity. Aib20 supports GIP activity, pharmacokinetics, and developability. These details describe why each engineered piece is present. They do not add a sequence string, and this page does not transcribe one.

At Lys17, a linker joins the C20 fatty diacid to the backbone (Coskun et al., Cell Metabolism, 2022). What that fatty-acid tail does to the half-life has its own evidence record. Here, the narrower point is chemical identity: the formula counts the atoms in the backbone and its modification together.

Why is retatrutide's PubChem record titled 'Triple G'?

Retatrutide's formula sits on PubChem CID 171390338 because that entry was deposited under the title "Triple G," not under the later drug name. As fetched on 2026-08-23, PubChem CID 171390338 listed Triple G, orb1981169, EX-A7826E, GTPL13769, and T76279 as synonyms, without the word retatrutide. The formula therefore connects to retatrutide through CAS Registry Number 2381089-83-2 and the NCATS Inxight Drugs entry under UNII NOP2Y096GV. The title gap is real, but the shared registry number supplies the identity trail that the title does not.

PubChem CID 171390338 also lists registry IDs CDMO2381089832, PI2381089832, and PR2381089832, plus Guide to Pharmacology ID 13769; each identifier carries the same CAS digits in that PubChem record. Those repeated digits make the trail easier to audit across databases.

Names are the loosest thing about a molecule. A database entry keeps whatever label someone typed when they deposited it, so names drift. A registry number is built to stay fixed while research names, development names, and public names change around it.

What is the molecular weight of retatrutide?

Retatrutide's molecular weight is 4731, and its exact mass is 4730.4784689, both published by PubChem CID 171390338. Molecular weight averages the natural mix of isotopes for each element. An isotope is one of the slightly different weights in which the same element occurs. Exact mass instead uses one specific set of isotopes from the formula. The values sit close together because they describe the same atom count in different ways, but they are not interchangeable. Neither figure is a purity reading or a measurement of material in a container.

PubChem CID 171934787 lists the same molecular weight of 4731 and exact mass of 4730.4784689 as PubChem CID 171390338. That match does not settle the salt question. It shows that the salt-named record repeated the parent listing, not that a separate measurement reached the same result. Two records agreeing is only reassuring when someone looked twice.

What are retatrutide's official identifiers?

Retatrutide's NCATS Inxight Drugs entry lists FDA UNII NOP2Y096GV, CAS Registry Number 2381089-83-2, INN number 12350, USAN code JK-35, and NCI Thesaurus code C190758. UNII means a unique ingredient identifier assigned by the FDA. A CAS Registry Number is a unique number assigned to a substance by the Chemical Abstracts Service. INN means International Nonproprietary Name, the WHO naming system. USAN means United States Adopted Name. These labels serve different catalogues, but they all help keep one chemical identity connected while ordinary names change.

Retatrutide can collect deposit titles, research labels, and public names while the identifiers remain stable. Readers sorting out those moving names can compare the chemistry behind retatrutide, Mounjaro, and Ozempic without treating a shared category as a shared molecule.

The NCATS Inxight Drugs identifiers table does not print a molecular formula. That gap is why PubChem CID 171390338 supplies the formula while NCATS supplies the identifiers. Keeping those jobs separate is more reliable than stretching either record beyond what it shows.

Does the molecular formula prove what is in research-use material?

No. A molecular formula describes one molecule by counting atoms. It is not a measurement of any physical material. It says nothing about purity, content, or the identity of a supplied substance. The formula and identifiers here describe the substance recorded under CAS Registry Number 2381089-83-2 by PubChem CID 171390338 and NCATS Inxight Drugs. The structure describes the peptide characterised by Coskun et al. in Cell Metabolism in 2022. Research material is neither a medicine nor a replacement for one, and it is not for use in humans or animals.

A certificate of analysis tied to the lot in front of you is the paperwork that speaks about a physical material. The catalogue entry for retatrutide reference material places that documentation beside availability, while the guide to peptide quality records shows the boundaries of those documents.

A registry formula is not a clinical outcome. Readers looking for results can see what the published trial measured without moving any trial result onto this chemistry page. Research-use reference material is also not the trial drug product studied in published research.